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brain slices  (TaKaRa)


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    TaKaRa brain slices
    Brain Slices, supplied by TaKaRa, used in various techniques. Bioz Stars score: 96/100, based on 253 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/brain+slices/pmc12296434-77-20-37?v=TaKaRa
    Average 96 stars, based on 253 article reviews
    brain slices - by Bioz Stars, 2026-06
    96/100 stars

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    (b) Live tumor cell bioluminescence four days post tumor tissue seeding on <t>OBSCs.</t> (c) pLGG microtumor replicate viability measured via bioluminescent flux, with four statistical outliers showing increased viability compared to the average survival of each microtumor (*statistical outlier measured using ROUT method, Prism). (d) pLGG-1 viability on OBSC compared to in vitro , showing a 43-fold increase in survival on OBSC (****p < 0.0001 compared to pLGG-1 microtumors in vitro using Welch’s t test, Prism).
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    Image Search Results


    (b) Live tumor cell bioluminescence four days post tumor tissue seeding on OBSCs. (c) pLGG microtumor replicate viability measured via bioluminescent flux, with four statistical outliers showing increased viability compared to the average survival of each microtumor (*statistical outlier measured using ROUT method, Prism). (d) pLGG-1 viability on OBSC compared to in vitro , showing a 43-fold increase in survival on OBSC (****p < 0.0001 compared to pLGG-1 microtumors in vitro using Welch’s t test, Prism).

    Journal: PLOS One

    Article Title: An ex vivo functional biomarker of treatment response in pediatric low-grade glioma

    doi: 10.1371/journal.pone.0331423

    Figure Lengend Snippet: (b) Live tumor cell bioluminescence four days post tumor tissue seeding on OBSCs. (c) pLGG microtumor replicate viability measured via bioluminescent flux, with four statistical outliers showing increased viability compared to the average survival of each microtumor (*statistical outlier measured using ROUT method, Prism). (d) pLGG-1 viability on OBSC compared to in vitro , showing a 43-fold increase in survival on OBSC (****p < 0.0001 compared to pLGG-1 microtumors in vitro using Welch’s t test, Prism).

    Article Snippet: We first tested the reproducible engraftment and survival of all three pLGG tumor tissues on SLiCE, which uses living organotypic brain slice cultures (OBSCs) from P8 Sprague-Dawley rat pups as living tissue substrates on which to engraft and treat patient tumor tissues.

    Techniques: In Vitro

    (a) RAS-MAPK pathway demonstrating the effects of the BRAF:KIAA 1549 fusion and targeted therapy with dabrafenib and trametinib. (b) Western blot of BRAF:KIAA 1549 + pLGG-1 cells seeded on organotypic brain slice cultures and treated with trametinib. (c) Western blot of BRAF:KIAA 1549 + pLGG-1 cells seeded on OBSCs and treated with dabrafenib. (d) Heatmap of trametinib treatment-induced protein levels of pMEK, tMEK, pERK, and tERK after 24 and 72 hours. (e) Heatmap of dabrafenib treatment-induced protein levels of pMEK, tMEK, pERK, and tERK after 24 and 72 hours. (f) Heatmap of normalized band intensities (pERK/tERK and pMEK/tMEK) for trametinib treatment at 24 h and 72 h. (g) Heatmap of normalized band intensities (pERK/tERK and pMEK/tMEK) for dabrafenib treatment at 24 h and 72 h.

    Journal: PLOS One

    Article Title: An ex vivo functional biomarker of treatment response in pediatric low-grade glioma

    doi: 10.1371/journal.pone.0331423

    Figure Lengend Snippet: (a) RAS-MAPK pathway demonstrating the effects of the BRAF:KIAA 1549 fusion and targeted therapy with dabrafenib and trametinib. (b) Western blot of BRAF:KIAA 1549 + pLGG-1 cells seeded on organotypic brain slice cultures and treated with trametinib. (c) Western blot of BRAF:KIAA 1549 + pLGG-1 cells seeded on OBSCs and treated with dabrafenib. (d) Heatmap of trametinib treatment-induced protein levels of pMEK, tMEK, pERK, and tERK after 24 and 72 hours. (e) Heatmap of dabrafenib treatment-induced protein levels of pMEK, tMEK, pERK, and tERK after 24 and 72 hours. (f) Heatmap of normalized band intensities (pERK/tERK and pMEK/tMEK) for trametinib treatment at 24 h and 72 h. (g) Heatmap of normalized band intensities (pERK/tERK and pMEK/tMEK) for dabrafenib treatment at 24 h and 72 h.

    Article Snippet: We first tested the reproducible engraftment and survival of all three pLGG tumor tissues on SLiCE, which uses living organotypic brain slice cultures (OBSCs) from P8 Sprague-Dawley rat pups as living tissue substrates on which to engraft and treat patient tumor tissues.

    Techniques: Western Blot, Slice Preparation